This study aimed to evaluate the therapeutic efficacy of a herbal-based formula as an adjunct to silymarin in mitigating paracetamol-induced hepatotoxicity in dogs. Fourteen dogs were experimentally induced with toxicity and divided into two equal groups (n=7). Group 1 (Herbal) was treated with silymarin plus a herbal formula, while Group 2 (Control) received only silymarin. Paracetamol induction caused a significant (P < 0.05) decline in erythrogram parameters (RBCs, HGB, HCT) and a significant elevation in liver enzymes (ALT, AST, ALKP), platelets, total cholesterol, and triglycerides. Treatment with the herbal formula significantly restored hematological values and led to a marked reduction in all elevated biochemical markers, showing superior restorative and hepatoprotective effects compared to the control group. Ultrasonography confirmed a near-complete resolution of hepatic lesions in the herbal-treated group. It is concluded that the tested herbal-based formula is a potent and beneficial adjunctive therapy for accelerating recovery from paracetamol-induced hepatotoxicity in dogs.
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